Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells
M Kumazaki, S Noguchi, Y Yasui, J Iwasaki… - The Journal of nutritional …, 2013 - Elsevier
Much evidence indicates that various naturally occurring compounds have an anti-cancer
effect, but the detailed mechanisms are not well understood. In this study, we selected anti-
cancer phytochemicals such as epigallocatechin-3-gallate (EGCG), resveratrol (RES) and α-
mangostin (α-M), all of which are well-characterized chemopreventive agents. We sought to
elucidate the mechanism of their anti-cancer effects and the synergistic effects obtained by
combined treatment with the anti-cancer drug 5-fluorouracil (5-FU) in three human colon …
effect, but the detailed mechanisms are not well understood. In this study, we selected anti-
cancer phytochemicals such as epigallocatechin-3-gallate (EGCG), resveratrol (RES) and α-
mangostin (α-M), all of which are well-characterized chemopreventive agents. We sought to
elucidate the mechanism of their anti-cancer effects and the synergistic effects obtained by
combined treatment with the anti-cancer drug 5-fluorouracil (5-FU) in three human colon …
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